
Your Custom Quiz
In Peng 2025 et al., on topical amikacin gel, what was the lower limit of quantification (LLOQ) for the assay used?
🔍 Key Findings
Objective: Determine if topical 45 mg/mL amikacin in CMC gel leads to systemic absorption in dogs with wounds.
Dogs enrolled: 11 client-owned dogs, with 31 applications of the gel.
Serum findings:
- Only 5 of 153 samples were above the 2.5 µg/mL quantification limit
- All values remained <5 µg/mL, the presumed toxicity threshold
- No correlation was found between dose-related parameters (mg, mg/kg, mg/cm²) and serum amikacin levels
Peak concentrations were observed at ~2 hours post-application, declining rapidly thereafter
No nephrotoxicity observed, and most values were below detection
Conclusion: Topical amikacin gel appears safe at doses up to 24.9 mg/kg, with minimal systemic absorption
Veterinary Surgery
3
2025
Serum amikacin concentrations in dogs with naturally occurring open wounds treated with topical amikacin in carboxymethylcellulose hydrogel
2025-3-VS-peng2-3
In Kang 2022 et al., on 3D scaffold reconstruction, what was one key advantage of using a patient-specific osteotomy guide?
🔍 Key Findings
- Patient-specific 3D-printed PCL/β-TCP scaffold enabled successful zygomatic arch reconstruction in a dog.
- Complete surgical resection of a zygomatic parosteal osteosarcoma was achieved, with a 0.3 mm histologically clean margin.
- Post-op imaging showed progressive tissue ingrowth into the scaffold, with Hounsfield Units increasing from 20.4 to 97.8 over 10 months.
- No complications (e.g., infection, displacement) or tumor recurrence were noted at 16-month follow-up.
- Use of a patient-specific osteotomy guide improved anatomical fit and facilitated precise excision and implant placement.
- Facial symmetry and orbital stability were maintained throughout follow-up.
- The scaffold remained structurally stable despite limited bone regeneration, suggesting connective tissue filled the defect.
- Topical mitomycin C was applied intraoperatively for possible anti-neoplastic effect, but efficacy remains unclear.
Veterinary Surgery
8
2022
Zygomatic arch reconstruction with a patient-specific polycaprolactone beta-tricalcium phosphate scaffold after parosteal osteosarcoma resection in a dog
2022-8-VS-kang-5
In Silveira 2022 et al., on GTO in canine THR, what was the cause of the one reported post-operative complication?
🔍 Key Findings
- GTO enabled successful cementless THR in dogs with severe medialization of the greater trochanter or chronic craniodorsal hip luxation.
- All 5 hips had acceptable long-term outcomes (median follow-up: 48 months) with full function and no persistent complications.
- Only one major complication occurred—a luxation unrelated to the GTO and successfully corrected with cup revision.
- GTO facilitated femoral canal access and gluteal preservation, reducing risk of iatrogenic injury during broaching.
- All GTOs healed radiographically (4 by 6 weeks, 1 by 12 weeks), with no cases of nonunion or implant migration.
- No complications related to GTO or PTBW fixation (pins + tension band) were observed in any dog.
- Surgical planning included templating both THR and GTO to ensure ideal alignment and reduce fracture risk.
- GTO may be especially valuable in luxoid hip dysplasia phenotypes or chronically fixed luxations.
Veterinary Surgery
2
2022
Greater trochanter osteotomy as a component of cementless total hip replacement: Five cases in four dogs
2022-2-VS-silveira-5
In Thomsen 2024 et al., on CT accuracy for liver tumors, which phase of contrast-enhanced CT was most helpful in localization?
🔍 Key Findings
- CT localization of liver masses was more accurate by division (88%) than by lobe (74.3%)
- Inter-radiologist agreement was excellent for division (kappa up to 0.885) and only moderate–good for lobe
- Quadrate and right lateral lobes had significantly lower localization accuracy compared to left lateral or medial lobes
- CT localization of the left division was most accurate (90.1%) compared to central (77.1%) and right (88.3%)
- Portal and hepatic venous phases were equally helpful for localization (each ~30–38% usefulness)
- No significant associations found between histopathologic diagnosis and localization accuracy
- Lobe-level CT localization should be interpreted with caution, especially for the quadrate and right lateral lobes
- Radiologist experience likely influenced accuracy, with the most experienced radiologist performing best
Veterinary Surgery
7
2024
Computed tomography scan accuracy for the prediction of lobe and division of liver tumors by four board-certified radiologists
2024-7-VS-thomsen-3
In McLean 2024 et al., which variables were found to have no significant association with rock-back?
🔍 Key Findings Summary
- 95 TPLO procedures reviewed retrospectively with follow-up radiographs
- Rock-back defined as increase in tibial plateau angle (TPA) ≥2° from immediate post-op to recheck
- 21% of stifles (20/95) experienced rock-back
- Mean ΔTPA among rock-back cases = 3.2° ± 2.6°
- No implant failures or tibial tuberosity fractures were reported in these cases
- Plate inclination and exit cut angle (ECA) were not associated with increased risk of rock-back (p = 0.4 and 0.2)
- Authors hypothesize that compression across osteotomy in vivo may mitigate torsional effects from ECA, unlike in gap-model studies
- Emphasizes that rock-back is relatively common, even with well-placed implants
Veterinary and Comparative Orthopedics and Traumatology
6
2024
Effect of Plate Inclination and Osteotomy Positioning on Rock-back following Tibial Plateau Levelling Osteotomy in Dogs
2024-6-VCOT-mclean-2
In Neal 2023 et al., on transcondylar screw placement, what was the observed rate of joint infringement when using the aiming device?
🔍 Key Findings
- Aiming device provided comparable trajectory accuracy to fluoroscopy, especially in right limbs (1.9° vs. 3.4°, p = .0128).
- Eccentricity (deviation from condylar center) was lower with fluoroscopy (3.1 mm vs 4.2 mm, p = .0017), making fluoroscopy more precise.
- Odds of joint infringement were 8× higher with the aiming device, though not statistically significant (p = .0575).
- Residents had greater screw trajectory deviation than diplomates (p = .0366), highlighting impact of experience.
- Aiming device procedures took less time than fluoroscopy in some scenarios, particularly for right limbs with right-handed surgeons.
- Fluoroscopic procedures had more pin/drill attempts, increasing risk of glove puncture and potential aseptic breaks.
- Mean deviation angles in both groups (<3.5°) were within acceptable range to avoid intracondylar fracture gap.
- Cadaver model used large-breed, healthy adult dogs, not small-breed immature dogs, limiting generalizability.
Veterinary Surgery
4
2023
The effect of an aiming device on the accuracy of humeral transcondylar screw placement
2023-4-VS-neal-3
In Ibrahim 2022 et al., on scrotal arterial supply, what was concluded regarding the use of scrotal flaps in neutered dogs?
🔍 Key Findings
- Dorsal scrotal arteries, branching from the ventral perineal arteries, are the dominant arterial supply to the scrotum in dogs.
- The ventral scrotal arteries, arising from the external pudendal arteries, perfused only the cranial scrotal border and were inconsistently present or absent in some dogs.
- A scrotal flap based on the dorsal scrotal arteries showed strong perfusion and may be a viable axial pattern flap.
- Perfusion was consistent across fresh and frozen cadavers, showing no difference due to preservation method.
- Poor flap survival (27%) occurred when based on cranial supply alone (i.e., ventral scrotal arteries), confirming importance of preserving caudal supply.
- There are anastomoses between dorsal and ventral scrotal arteries, offering collateral flow but insufficient alone for complete perfusion.
- Scrotal flaps based on the caudal pedicle may be applicable for reconstruction of proximal medial/lateral thigh wounds.
- Proposed flap requires careful preservation of ventral perineal arteries, ideally designed 2.5–3 cm lateral to midline in large dogs.
Veterinary Surgery
4
2022
Arterial supply to the scrotum: A cadaveric angiographic study
2022-4-VS-ibrahim-4
In Murphy 2024 et al., which breeds had significantly lower odds of contralateral CCLR?
🔍 Key Findings Summary
- Prevalence of contralateral CCLR in dogs ≥8 years and ≥15kg was 19.1%, notably lower than previous studies (33–50%).
- Median time to contralateral CCLR was 12.9 months.
- Older age reduced risk — 2% decrease per month of age (p=0.003).
- Golden Retrievers and Labradors had significantly lower risk (p=0.028 and p=0.007, respectively).
- No effect found from TPA, meniscal injury, or comorbidities (e.g., hip dysplasia, hypothyroidism).
Veterinary and Comparative Orthopedics and Traumatology
1
2024
The Prevalence and Risk Factors of Contralateral Cranial Cruciate Ligament Rupture in Medium-to-Large (≥15kg) Breed Dogs 8 Years of Age or Older
2024-1-VCOT-murphy-4
In Miller 2024 et al., how did rates of revision surgery compare between FFP and staphylectomy?
🔍 Key Findings Summary
- Sample: 124 dogs (64 S, 60 FFP); French Bulldogs most common (54/124)
- Pre-op clinical signs: Exercise intolerance (34/124), stertor (22), regurgitation (7), vomiting (12)
- Operative time (no concurrent procedure): Longer in FFP (75 vs 51 min, p = .02)
- Anesthetic time: Longer in FFP (111 vs 80 min, p = .02)
- Anesthetic complications: Similar rates (FFP 50, S 49; p = .30)
- Post-op regurgitation: 27/124 (S: 17, FFP: 10; p = .18)
- Post-op aspiration pneumonia: Rare (S: 4, FFP: 5)
- Major complications: Rare (5/124); 2 dogs euthanized post-op (1 per group)
- Revision surgery: Needed in 7/124 (3 S, 4 FFP)
Veterinary Surgery
1
2024
Complications and outcome following staphylectomy and folded flap palatoplasty in dogs with brachycephalic obstructive airway syndrome
2024-1-VS-miller-4
In Buote 2023 et al., on laparoscopic gastrectomy in cats, what was the primary purpose of the cadaveric phase of the study?
🔍 Key Findings
- LVSG was feasible in 9/10 feline cadavers with successful stapled gastrectomy and minimal technical complications.
- Stenosis at the incisura angularis occurred in 2/10 cadavers, associated with staple placement too close to the lesser curvature.
- Leak testing was negative in 8 cadavers and both live cats, indicating effective staple sealing.
- Mean stomach resection was ~28%, though less than human standards (~75–80%) for metabolic effects.
- Surgery was performed safely in two live feline subjects, with no intraoperative or postoperative complications over a 6-month follow-up.
- Technique refinements included orogastric tube placement and custom 3D-printed cannulas to improve staple line accuracy and avoid stenosis.
- Tri-Staple purple cartridges provided graduated compression suited for feline gastric tissue thickness (~2.5 mm).
- No need for staple line oversew in live cats; staple-only closure proved safe in this short-term study.
Veterinary Surgery
6
2023
Laparoscopic vertical sleeve gastrectomy in felines: A cadaveric feasibility study and experimental case series in two cats
2023-6-buote2-5
Quiz Results
You answered 7 out of 10 questions correctly
Key Findings
