"Be A Leader  
in reducing antibiotic use" 
(Use the Human Surgeon’s Non-antibiotic Method for removing bacteria & biofilms in-surgery)

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"Be A Leader
in reducing antibiotics use"
Use the Human  Surgeon's 
Non-Antibiotic Method for 
in-surgery removal of bacteria and biofilms 
(Without Having To Hire or Rely On A Tech Team!)
See the Data:
Join the growing number of veterinary surgeons  
Using Simini Protect Lavage to add supplemental
protection from bacteria and biofilms as they
align their antibiotic use with global health institutions

What's Simini Protect?

What You Need to Know

 Simini Protect Lavage

  • Intra-Op Protection: Applied just before suturing
  • ​Removed 99.98% of bacteria in a clinical study (1)
  • Designed to remove biofilms and resistant bacteria (MRSP)
  • ​Simini Protect products are non-antibiotic
  • ​Surgery Sam, our free app, prepares clients for surgery, and insures clients do the right things at the right time

40,000 Surgeries and counting

Between veterinary and human surgeons, these products have uniquely helped reduce bacteria and biofilms for thousands of patients.
  • Published studies of clinical outcomes (see below)

Now Available to 
Veterinary Surgeons

  • Locally Administered Product vs. systemically
  • Applied at time of highest risk (during surgery)
  • ​Short Product Exposure: Aligned with international guidelines (3), (4)
  • ​Non-antibiotic product and no new techniques

Free App for Clients to manage
TPLO/TTA recovery at home

  • Videos to prepare clients for surgery day
  • Daily checklists and videos to keep on top of recovery activities
  • ​​Videos to answer the most frequently asked questions 
  • ​Demonstration videos of the most common rehab exercises
  • ​Easy to download and install, just visit www.surgerysam.com

Safety Studies 

  •  Completed safety studies required for human medical device clearance (5),(6)
  • ​Successful studies have demonstrated Simini Protect Lavage compatibility with orthopedic implants and materials

Not Sure What Procedures You Would Use Simini Protect?

Simini Protect can be used for most types of surgical orthopedic procedures with the exception of application to eyes and ears, abdomen and thorax.
  • Orthopedics (including implants - TPLO)
  • Emergency & Trauma
  • ​Fractures 
  • ​Revision surgeries

Some Cases with 
Simini Protect

Dr. Aldo Vezzoni
Cremona, Italy

Dr. Aldo Vezzoni
Cremona, Italy

Veterinary Clinic
Guelph, Canada

Here Are A Few Other FAQs We Get A Lot:

How are these products different from current veterinary offerings?
Bacteria create biofilms to protect themselves.  Simini products allow you to remove biofilm and expose bacteria for optimal removal.
What's in Simini Protect Products?
The Simini Protect products have a patented formulation of ingredients.  Simini Protect Lavage contains ethanol, acetic acid, sodium acetate, benzalkonium chloride and water.   Simini Protect Gel contains polyethlene glycol, citric acid, sodium citrate, benzalkonium chloride and water.
What types of efficacy studies have been performed?
These products have been evaluated in laboratory tests (in vitro), biofilm tests (in the presence of bacteria’s natural amour), animal models (in-vivo studies) and a human clinical study (1).  
If I have questions, is there someone I can talk to?
Yes. Email cd@simini.com or call (647) 292-4920 anytime.
What types of procedures can they be used for and not used for?
The Simini Protect Lavage can be used for orthopedic surgeries and in the cases of trauma, emergency in the veterinary clinic.
The Simini Protect Lavage cannot be used in the eyes or ears or in the abdomen or thorax.
How do you use the Simini Protect Lavage?
Just prior to suturing, lavage with the Simini Protect Lavage as you would with normal saline. The solution is then rinsed with an equal amount of saline or water. See product label for full details.
What types of safety studies have been performed?
The Simini Protect Lavage has completed all the necessary safety testing to achieve human medical device product clearance.

Publications

(1) Hunter et al., “Clinical Effectiveness of a Biofilm Disrupting Surgical Lavage in Reducing Bacterial Contamination in Total Knee Arthroplasty Revision Surgery in Known Cases of Prosthetic Joint Infection”, Zimmer Biomet white paper.  (administered 1 litre volume via pulsed jet lavage)

(2) Premkumar A, et al. "Comparing the Efficacy of Irrigation Solutions on Staphylococcal Biofilm Formed on Arthroplasty Surfaces." J Arthroplasty. 2021 Feb 16:S0883-5403(21)00172-8. doi: 10.1016/j.arth.2021.02.033. Epub ahead of print. PMID: 33750633.

(3) Global guidelines for the prevention of surgical site infection, second edition. Geneva: World Health Organization

 (4) Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery; jointly by the Infectious Diseases Society of America (IDSA), the Surgical Infection Society (SIS), and the Society for Healthcare Epidemiology of America (SHEA) ; 2018


Safety Studies

(5) ISO Intramuscular Implantation Test with Histopathology (14 Day Rabbit Study) 
Simini Protect Lavage - No abnormal clinical signs, Lavage was considered "Non-Irritant" compared to predicate device.

(6) Dermal Testing - Uninfected wounds (14 Day Porcine Study)
Simini Protect Lavage resulted in normal wound healing and was comparable to a predicate device.

Copyright 2021 Simini Technologies Inc.