your patients
and your practice" 
(Use the human surgeon's secret 
to remove bacteria & biofilms)

Click on Video to Hear Sound

your patients"
Removal of 
 bacteria & biofilms

(Without Having To Hire or Rely On A Tech Team!)
See the Data:
Join the growing number of veterinary surgeons  
Adding intra-operative protection
Removing biofilms and resistant bacteria
Managing two of the greatest infection risks

Clinical Study in high-risk primary and revision surgeries

What is Simini ?

What Exactly is the Difference between Simini and What I Do

 Simini Protect Lavage

  • Simini Protect: Non-antibiotic lavage applied just before suturing
  • ​Removed 99.98% of bacteria in a clinical study (1)
  • Designed to remove biofilms and resistant bacteria (MRSP)
  • ​Can be used in both primary and revision surgeries

Simini Protect Lavage

  • Locally Administered Product vs. systemically
  • ​Applied at time of highest risk (during surgery)
  • ​Short Product Exposure: Aligned with international guidelines (3), (4)
  • ​Non-antibiotic product and no new techniques
  • Published studies of clinical outcomes (see below)
  • Biofilms form quickly:  In as little as 20 minutes (less than the time for an average TPLO procedure)
  • ​Bacteria more resistant: Up to 1000X more resistant when in biofilm
  • ​Removed 99.98% of bacteria: Clinical trial result with Simini Protect Lavage fluid (1)

Be Recognized as a 
"Sustainable Vet"

  • Antibiotic Stewardship is a leading sustainability issue in animal health
  • Protect pets, people and planet by using antibiotics responsibly
  •  Clients appreciate the care for their pet and their community

Safety Studies 

  •  Completed safety studies required for human medical device clearance (5),(6)
  • ​Successful studies have demonstrated Simini Protect Lavage compatibility with orthopedic implants and materials

Not Sure What Procedures You Would Use Simini Protect?

Simini Protect  Lavage can be used for most types of surgical orthopedic procedures.  Simini Protect Lavage cannot be used in the eyes and ears, abdomen and thorax.
  • Orthopedics (including implants - TPLO)
  • Emergency & Trauma
  • ​Fractures 
  • ​Revision surgeries

Some Cases with 
Simini Protect

Dr. Aldo Vezzoni
Cremona, Italy

Dr. Aldo Vezzoni
Cremona, Italy

Here Are A Few Other FAQs We Get A Lot:

How are these products different from current veterinary offerings?
Bacteria create biofilms to protect themselves.  Simini Protect Lavage allows you to remove biofilm and expose bacteria for optimal removal.
What's in Simini Protect Products?
The Simini Protect products have a patented formulation of ingredients.  Simini Protect Lavage contains ethanol, acetic acid, sodium acetate, benzalkonium chloride and water.   
What types of efficacy studies have been performed?
These products have been evaluated in laboratory tests (in vitro), biofilm tests (in the presence of bacteria’s natural amour), animal models (in-vivo studies) and a human clinical study (1).  
If I have questions, is there someone I can talk to?
Yes. Email cd@simini.com or call (647) 292-4920 anytime.
What types of procedures can they be used for and not used for?
The Simini Protect Lavage can be used for orthopedic surgeries and in the cases of trauma, emergency in the veterinary clinic.
The Simini Protect Lavage cannot be used in the eyes or ears or in the abdomen or thorax.
How do you use the Simini Protect Lavage?
Just prior to suturing, lavage with the Simini Protect Lavage as you would with normal saline. The solution is then rinsed with copious amounts of saline, as surgeons usually lavage wounds. See product label for full details.
What types of safety studies have been performed?
The Simini Protect Lavage has completed all the necessary safety testing to achieve human medical device product clearance.


(1) Hunter et al., “Clinical Effectiveness of a Biofilm Disrupting Surgical Lavage in Reducing Bacterial Contamination in Total Knee Arthroplasty Revision Surgery in Known Cases of Prosthetic Joint Infection”, Zimmer Biomet white paper.  (administered 1 litre volume via pulsed jet lavage)

(2) Premkumar A, et al. "Comparing the Efficacy of Irrigation Solutions on Staphylococcal Biofilm Formed on Arthroplasty Surfaces." J Arthroplasty. 2021 Feb 16:S0883-5403(21)00172-8. doi: 10.1016/j.arth.2021.02.033. Epub ahead of print. PMID: 33750633.

(3) Global guidelines for the prevention of surgical site infection, second edition. Geneva: World Health Organization

 (4) Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery; jointly by the Infectious Diseases Society of America (IDSA), the Surgical Infection Society (SIS), and the Society for Healthcare Epidemiology of America (SHEA) ; 2018

Safety Studies

(5) ISO Intramuscular Implantation Test with Histopathology (14 Day Rabbit Study) 
Simini Protect Lavage - No abnormal clinical signs, Lavage was considered "Non-Irritant" compared to predicate device.

(6) Dermal Testing - Uninfected wounds (14 Day Porcine Study)
Simini Protect Lavage resulted in normal wound healing and was comparable to a predicate device.