Quiz Question

In Low 2025 et al., on gonadectomy and CrCLD, what was the pooled odds ratio for male Labrador retrievers that were gonadectomized versus intact?

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Correct. Male Labrador retrievers had a significantly increased risk of CrCLD following gonadectomy, with a pooled OR of 2.13.

Incorrect. The correct answer is 2.13 (95% CI: 1.53–2.98).
Male Labrador retrievers had a significantly increased risk of CrCLD following gonadectomy, with a pooled OR of 2.13.

🔍 Key Findings

Increased risk with gonadectomy:

Pooled OR for CrCLD:
- Females: 2.29 (95% CI: 1.77–2.95)
- Males: 2.12 (95% CI: 1.67–2.69)

Early gonadectomy (≤1 year) further increased risk:

OR vs >1 year:
- Females: 3.39
- Males: 3.13

Late gonadectomy (>1 year) had no significant difference vs intact dogs.

Breed-specific findings:

Female Labradors: No increased CrCLD risk from gonadectomy (OR = 1.19; 95% CI: 0.54–2.64)
Male Labradors: Increased risk persisted (OR = 2.13; 95% CI: 1.53–2.98)

Study type: Systematic review + meta-analysis of 24 observational studies (n = 1.85 million dogs)

Low

Veterinary Surgery

2025

The association between gonadectomy and timing of gonadectomy, and the risk of canine cranial cruciate ligament disease: A systematic review and meta-analysis

2025-2-VS-low-3

Article Title: The association between gonadectomy and timing of gonadectomy, and the risk of canine cranial cruciate ligament disease: A systematic review and meta-analysis

Journal: Veterinary Surgery

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Topic: Breed-specific Risk

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