🔍 Key Findings

• NIRF altered surgical strategy in 3 of 20 GDV dogs, identifying necrosis not appreciated subjectively.
• Fundic fluorescence <10% indicated histologically confirmed gastric necrosis.
• In 1 dog, NIRF revealed nonviability despite the surgeon’s impression of viability.
• Staple line fluorescence resembled viable tissue in the only stapled gastrectomy, suggesting preservation of perfusion.
• GDV dogs (even “viable”) showed lower fluorescence vs. healthy controls, indicating subclinical vascular compromise.
• Histology confirmed full-thickness necrosis in all 4 dogs with NIRF-defined nonviability.
• Pre-op lactate was significantly higher in nonviable GDV dogs (8.55 vs 4.89 mmol/L, p=0.03).
• No complications were reported from ICG use; imaging was safe and repeatable.

🔍 Key Findings

• Esophageal pH-monitoring was well tolerated in all 35 nonbrachycephalic dogs, with no major adverse events reported.
• Distal GER occurred in 80% of dogs, but events were typically brief and non-productive; proximal GER occurred in only 39%.
• Upper reference limits for GER were 2.4 events/hour (distal) and 0.4 events/hour (proximal).
• Cumulative acid exposure was minimal: upper limits were 2.3% (distal) and 0% (proximal).
• Comparison with brachycephalic dogs shows significantly higher GER frequency and duration, validating the diagnostic utility of pH monitoring.
• Transnasal probe placement under light anesthesia was safe and less morbid compared to percutaneous or conscious techniques.
• No expelled or productive regurgitation occurred, despite some GER events, indicating efficient esophageal clearance in healthy dogs.
• Diet and fasting duration may affect GER, but these were not controlled variables in this study.

🔍 Key Findings

• Double-loop cerclage resisted the highest peak load (805 N) and maintained tension longer than twist (488 N) and single-loop (397 N) configurations.
• Double-loop cerclage sustained 500,000 cycles at 60–80% of peak load in some cases without loosening, outperforming other types.
• Twist knots loosened rapidly, often within 10 cycles even at low loads (100–390 N).
• Single-loop knots performed better than twist, with partial resistance up to 100,000 cycles at 160 N, but showed wide variability.
• All loosening occurred before wire breakage, indicating clinical failure would happen from slack, not fracture.
• Double-loop cerclage had highest initial tension (323 N) compared to single-loop (124 N) and twist (69 N).
• Fatigue limit was not identified for twist, since they all loosened early at even 20% of peak load.
• Clinical recommendation: double-loop cerclage is best for resisting repeated subfailure loading, ideal for fissure prevention or fragment stabilization.

🔍 Key Findings Summary

• Study Design: Retrospective study of 100 radiographs using in silico and clinical data
• Mean preoperative TPA: 28.6°, higher in small dogs than large (p = .02)
• Mean planned TPA (in silico): 7.6°, not achieving 5° target (p < .01)
• Median postoperative TPA: 5.5° overall; higher in small dogs (7°) vs large (4.5°) (p = .06)
• Postoperative ostectomy position: More distal than recommended; average = 8.6 mm
• Increased distalization → greater under-correction of TPA (p = .01)
• Most accurate correction occurred when ostectomy was ≤7.5 mm from patellar tendon
• Wedge angle categories (TPA-Pre minus 5–2°) were used based on pre-op TPA

🔍 Key Findings

• Nasopharyngeal collapse was significantly more severe in brachycephalic dogs (median 65%) than in nonbrachycephalic controls (median 10%) (p = .0001).
• Postoperative fluoroscopy showed no significant improvement in nasopharyngeal collapse (p = .0505), despite reported clinical improvement.
• 70% of brachycephalic dogs had ≥50% collapse; 26% had 100% collapse preoperatively.
• All owners of surgical cases reported clinical improvement, including reduced respiratory noise and improved exercise tolerance.
• Surgical techniques used included combinations of alaplasty, staphylectomy, sacculectomy, and tonsillectomy.
• Improvement in nasopharyngeal dimensions was variable, with some dogs improving ≥45%, some worsening, and one dog showing a 100% increase post-op.
• Pharyngeal collapse may not be solely anatomical; neuromuscular dysfunction (e.g., reduced pharyngeal dilator muscle function) may contribute.
• Current surgical techniques may not address functional airway abnormalities, suggesting a need for multimodal or targeted interventions.

🔍 Key Findings

PL-30 group (partial, TA30-V3 wedge):

• 100% leaked
• Median leakage pressure: 10 cm H₂O
• Most failures from periphery of staple line

PL-60 group (partial, TA60-3.5):

• 100% leaked
• Median leakage pressure: 18 cm H₂O
• Better than PL-30 (p = .006)

TL-30 group (total, TA30-V3):

• Only 1 of 11 leaked (at 22 cm H₂O)
• All others resisted pressures >50–65 cm H₂O
• Significantly higher leakage pressure than both PL groups (p < .001)

Odds ratios (leakage vs TL-30):

• PL-30: OR 437 at both 20 and 30 cm H₂O (p = .003)
• PL-60: OR 437 at 20 cm H₂O and 133 at 30 cm H₂O (p = .003)

Recommendation: Prefer TL-30 when possible. If partial needed, PL-60 superior to PL-30, but all partials leaked at physiologic pressures.

🔍 Key Findings

• TPLO with the contoured saw guide achieved more accurate osteotomy angles for both inclination and torsion in bone models and cadaveric limbs (p < .05).
• Medial cortical damage was significantly lower with the contoured guide (247 vs. 1866 pixels in bone models; p < .001).
• No significant difference in eccentricity (distance between actual and intended osteotomy center) was found between groups.
• Postoperative tibial plateau angle (TPA) was similar between groups (6.4° vs. 7.6°; p = .15), though both were slightly higher than the target of 6°.
• Deviation in medial mechanical proximal tibial angle (mMPTA) showed no significant group difference; valgus deformity occurred in both.
• Osteotomy and device application times were similar between the contoured guide and jig-assisted TPLO.
• The contoured guide eliminated the need for proximal jig pin, potentially reducing intra-articular pin risk.
• The guide's multiple pin fixation system improved stability and alignment, supporting safer osteotomy on curved tibial surfaces.

🔍 Key Findings

• TPLO mRUST scoring showed improved inter-rater reliability (ICC = 0.56) compared to subjective evaluation (Kappa = 0.33).
• Intra-rater reliability was similar for both methods (TPLO mRUST: 0.73, subjective: 0.72).
• TPLO mRUST scores ≥10/12 strongly correlated with radiographic union, as subjectively assessed (99% agreement).
• No significant difference in healing between first and second TPLO sides (P = .09), countering assumptions about load-bearing impact.
• Higher initial lameness scores and younger age were associated with higher TPLO mRUST scores, suggesting more robust healing in those groups.
• Postoperative complications were linked to lower TPLO mRUST scores, indicating impaired healing.
• Medial cortex was excluded from scoring due to plate obstruction, validating use of only 3 cortices for scoring.
• The TPLO mRUST system may standardize healing assessment, reducing subjective bias across specialties.

🔍 Key Findings Summary

• Subjects: 12 healthy colony cats, 68 total liver samples collected via laparoscopy
• Biopsy instruments: 3 mm vs 5 mm Storz Blakesley cup forceps
• Techniques: Twist (T), Pull (P), Twist + Pull (TP)
• Results:
  • 5 mm forceps yielded significantly more hepatic lobules (mean 12.4 vs 4.9), portal triads (29.6 vs 19.0), weight, and histologic area (p < .01)
  • T and P techniques yielded more portal triads and lobules than TP (p = .003 and p = .015)
  • TP technique resulted in greater tissue crush vs T (p = .01)
  • Good diagnostic agreement between 3 mm and 5 mm samples only with TP (κ = 0.75)
  • All samples were of sufficient diagnostic quality, despite size or technique
• Clinical implication: Both 3 mm and 5 mm forceps are viable; further studies are needed to confirm diagnostic accuracy of 3 mm samples

🔍 Key Findings

• CBPI, COI, and LOAD are recommended for assessing canine osteoarthritis based on COSMIN criteria.
• COI scored highest in development rigor and evidence quality among evaluated OROMs.
• Internal consistency, reliability, and responsiveness were commonly validated, though no OROMs reported measurement error.
• LOAD was considered formative, and internal consistency assessment was deemed unnecessary.
• CBPI and COI showed sufficient internal consistency, but CBPI’s factor structure was inconsistent across studies.
• All 6 evaluated OROMs (CBPI, COI, LOAD, BHSII, HCPI, HVAS) were quick to complete (under 5 min).
• Three tools—BHSII, HCPI, HVAS—need more evidence before recommendation; only CBPI, COI, and LOAD are Category A (recommended).
• Future studies should assess interpretability, including measurement error and clinically meaningful change scores (MIC, SDC).