Investigation of the “R” tumor margin classification and prognostic factors in apocrine gland anal sac adenocarcinoma of dogs
🔍 Key Findings
- R0 margins were achieved in 75.7% of dogs (56/74), demonstrating that complete histologic excision is feasible for most AGASACAs.
- R1 margins increased local recurrence risk 23-fold; recurrence occurred in 50% of R1 cases versus 4% of R0 cases (p < .0001).
- Median survival time was 25 months (95% CI 21–33 months) following surgery.
- Preoperative hypercalcemia was a major negative prognostic factor, reducing MST to 7.5 months (p = .012).
- Metastatic disease at diagnosis shortened survival (MST 17 vs 29 months; p = .005).
- Lymphovascular invasion predicted both metastasis and poorer survival, with an 8.3-fold increased risk of subsequent metastatic disease and MST of 21 months.
- Increasing mitotic count was associated with increased mortality risk (HR 1.13 per 5-unit increase; p = .0069).
- Adjunct therapy improved survival, whereas absence of adjunct treatment increased mortality risk (HR 0.16 for treated dogs).
Simini Surgery Review Podcast
🔍 Key Findings
- R0 margins were achieved in 75.7% of dogs (56/74), demonstrating that complete histologic excision is feasible for most AGASACAs.
- R1 margins increased local recurrence risk 23-fold; recurrence occurred in 50% of R1 cases versus 4% of R0 cases (p < .0001).
- Median survival time was 25 months (95% CI 21–33 months) following surgery.
- Preoperative hypercalcemia was a major negative prognostic factor, reducing MST to 7.5 months (p = .012).
- Metastatic disease at diagnosis shortened survival (MST 17 vs 29 months; p = .005).
- Lymphovascular invasion predicted both metastasis and poorer survival, with an 8.3-fold increased risk of subsequent metastatic disease and MST of 21 months.
- Increasing mitotic count was associated with increased mortality risk (HR 1.13 per 5-unit increase; p = .0069).
- Adjunct therapy improved survival, whereas absence of adjunct treatment increased mortality risk (HR 0.16 for treated dogs).
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