← Articles

Kurogochi et al: Saline‐based modified del Nido cardioplegia versus multidose St. Thomas cardioplegia in canine mitral valve repair: A randomized controlled trial
Veterinary Surgery 7, 2025

🔍 Key Findings

  • No significant difference in cardiac troponin I levels 12h post-op between mDN and St. Thomas cardioplegia groups (p = 0.478)
  • Sinus rhythm returned faster in the mDN group after aortic cross-clamp removal (median 60s vs 362s, p = 0.027)
  • Lower serum potassium at cross-clamp removal in the mDN group (median 4.5 mEq/L vs 5.4, p = 0.005)
  • Fewer doses needed in the mDN group (median 2.5 vs 4.0, p = 0.040)
  • Higher total crystalloid volume used in mDN group (23.6 vs 12.6 mL/kg, p < 0.001)
  • No difference in survival (700-day survival 90% in both groups, p = 0.958)
  • No difference in hospitalization duration (median 6 days for both, p = 0.789)
  • Echocardiographic remodeling similar between groups at 24h post-op

Simini Surgery Review Podcast

How critical is this paper for crushing the Boards?

🚨 Must-know. I’d bet on seeing this.

📚 Useful background, not must-know.

💤 Skip it. Doubt it’ll ever show up.

Thanks for the feedback!
‍We'll keep fine-tuning the articles vault.
Oops — didn’t go through.
‍Mind trying that again?
← Articles

Kurogochi et al: Saline‐based modified del Nido cardioplegia versus multidose St. Thomas cardioplegia in canine mitral valve repair: A randomized controlled trial
Veterinary Surgery 7, 2025

🔍 Key Findings

  • No significant difference in cardiac troponin I levels 12h post-op between mDN and St. Thomas cardioplegia groups (p = 0.478)
  • Sinus rhythm returned faster in the mDN group after aortic cross-clamp removal (median 60s vs 362s, p = 0.027)
  • Lower serum potassium at cross-clamp removal in the mDN group (median 4.5 mEq/L vs 5.4, p = 0.005)
  • Fewer doses needed in the mDN group (median 2.5 vs 4.0, p = 0.040)
  • Higher total crystalloid volume used in mDN group (23.6 vs 12.6 mL/kg, p < 0.001)
  • No difference in survival (700-day survival 90% in both groups, p = 0.958)
  • No difference in hospitalization duration (median 6 days for both, p = 0.789)
  • Echocardiographic remodeling similar between groups at 24h post-op

Simini Surgery Review Podcast

Know What Matters in the Literature - and Why

We distill peer-reviewed surgical studies into clinically relevant summaries and
exam-style questions, so you can make informed decisions with confidence.

Free Access. No Spam. Just Smarter Surgical Learning

Multiple Choice Questions on this study

In Kurogochi 2025 et al., on cardioplegia in mitral repair, what was concluded about long-term outcomes between groups?

A. mDN had higher survival at 700 days
B. Control group had better hospitalization outcomes
C. No differences in survival or hospitalization duration
D. mDN had lower discharge rates
E. mDN was associated with more complications

Answer: No differences in survival or hospitalization duration

Explanation: Survival at 700 days was 90% in both groups; hospital stay was median 6 days.
In Kurogochi 2025 et al., on cardioplegia in mitral repair, what difference was found in serum potassium at cross-clamp removal?

A. Potassium was higher in the mDN group
B. Potassium was equal between groups
C. Potassium was higher in control group
D. Potassium was below normal in both groups
E. Potassium was unmeasurable in mDN group

Answer: Potassium was higher in control group

Explanation: Potassium at cross-clamp removal was higher in control group (5.4 vs 4.5 mEq/L, p = 0.005).
In Kurogochi 2025 et al., on cardioplegia in mitral repair, what was the effect of mDN solution on sinus rhythm recovery?

A. It delayed sinus rhythm recovery compared to the control group
B. It had no significant impact on sinus rhythm recovery
C. It resulted in significantly faster sinus rhythm recovery
D. It led to a higher defibrillation rate
E. It caused arrhythmias post-cross-clamp

Answer: It resulted in significantly faster sinus rhythm recovery

Explanation: Faster sinus rhythm recovery in the mDN group (60s vs 362s, p = 0.027) suggests electrical stabilization benefits.
In Kurogochi 2025 et al., on cardioplegia in mitral repair, what was the main finding regarding serum cardiac troponin I levels 12 hours post-op?

A. They were significantly lower in the mDN group
B. They were significantly higher in the mDN group
C. They were comparable between both groups
D. Only control group showed elevation
E. Only mDN group showed elevation

Answer: They were comparable between both groups

Explanation: There was no significant difference in cTnI levels at 12h post-op (p = 0.478).
In Kurogochi 2025 et al., on cardioplegia in mitral repair, how did the number of cardioplegia doses differ between groups?

A. mDN group required more doses
B. Control group required fewer doses
C. Both groups required the same doses
D. mDN group received none
E. Dosing was not reported

Answer: Control group required fewer doses

Explanation: mDN group needed fewer total doses (median 2.5 vs 4, p = 0.040).

Access the full library of surgical summaries and exam-style questions.

Get Instant Access

Educational content developed independently and supported by Simini.

The maker of Simini Protect Lavage.

Review More Key Summaries from this Veterinary Surgery Journal Issue

Welker

 et al: 

Anastomosis of the caudal thoracic duct and intercostal vein using a microvascular anastomotic coupler device: Experimental study in six dogs

Thomsen

 et al: 

Computed tomography scan accuracy for the prediction of lobe and division of liver tumors by four board-certified radiologists

Davies

 et al: 

Lymphaticovenous anastomosis of the caudal thoracic duct to the azygous vein: A feline cadaver study

Petchell

 et al: 

An in silico comparison of a novel CORA-based cranial closing wedge ostectomy methodology with three other techniques

Buote

 et al: 

3D printed cannulas for use in laparoscopic surgery in feline patients: A cadaveric study and case series