🔍 Key Findings
Objective: Determine if topical 45 mg/mL amikacin in CMC gel leads to systemic absorption in dogs with wounds.
Dogs enrolled: 11 client-owned dogs, with 31 applications of the gel.
Serum findings:
- Only 5 of 153 samples were above the 2.5 µg/mL quantification limit
- All values remained <5 µg/mL, the presumed toxicity threshold
- No correlation was found between dose-related parameters (mg, mg/kg, mg/cm²) and serum amikacin levels
Peak concentrations were observed at ~2 hours post-application, declining rapidly thereafter
No nephrotoxicity observed, and most values were below detection
Conclusion: Topical amikacin gel appears safe at doses up to 24.9 mg/kg, with minimal systemic absorption
Simini Surgery Review Podcast
🔍 Key Findings
Objective: Determine if topical 45 mg/mL amikacin in CMC gel leads to systemic absorption in dogs with wounds.
Dogs enrolled: 11 client-owned dogs, with 31 applications of the gel.
Serum findings:
- Only 5 of 153 samples were above the 2.5 µg/mL quantification limit
- All values remained <5 µg/mL, the presumed toxicity threshold
- No correlation was found between dose-related parameters (mg, mg/kg, mg/cm²) and serum amikacin levels
Peak concentrations were observed at ~2 hours post-application, declining rapidly thereafter
No nephrotoxicity observed, and most values were below detection
Conclusion: Topical amikacin gel appears safe at doses up to 24.9 mg/kg, with minimal systemic absorption
Simini Surgery Review Podcast
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