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Paul et al: Comparison of bupivacaine liposome injectable solution and fentanyl for postoperative analgesia in dogs undergoing limb amputation
Veterinary Surgery 6, 2024

🔍 Key Findings

  • BLIS (bupivacaine liposome injectable solution) provided equivalent analgesia to fentanyl CRI based on CMPS-SF scores at all time points except 6h, where BLIS was superior
  • Fewer adverse effects (nausea, vomiting, sedation) were noted in the BLIS group
  • BLIS dogs ate sooner postoperatively (median 6h vs 9h in control)
  • Sedation occurred in 2/20 dogs in BLIS group vs 10/20 in fentanyl group
  • Vomiting occurred in 0/20 BLIS dogs vs 4/20 in fentanyl group
  • Rescue analgesia rates were similar (5 BLIS vs 4 fentanyl group), confirming noninferiority
  • Owner-reported VAS scores were lower for BLIS on day 1 a.m. and p.m. despite variability
  • Results suggest BLIS could reduce opioid reliance post-amputation

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← Articles

Paul et al: Comparison of bupivacaine liposome injectable solution and fentanyl for postoperative analgesia in dogs undergoing limb amputation
Veterinary Surgery 6, 2024

🔍 Key Findings

  • BLIS (bupivacaine liposome injectable solution) provided equivalent analgesia to fentanyl CRI based on CMPS-SF scores at all time points except 6h, where BLIS was superior
  • Fewer adverse effects (nausea, vomiting, sedation) were noted in the BLIS group
  • BLIS dogs ate sooner postoperatively (median 6h vs 9h in control)
  • Sedation occurred in 2/20 dogs in BLIS group vs 10/20 in fentanyl group
  • Vomiting occurred in 0/20 BLIS dogs vs 4/20 in fentanyl group
  • Rescue analgesia rates were similar (5 BLIS vs 4 fentanyl group), confirming noninferiority
  • Owner-reported VAS scores were lower for BLIS on day 1 a.m. and p.m. despite variability
  • Results suggest BLIS could reduce opioid reliance post-amputation

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Multiple Choice Questions on this study

In Paul 2024 et al., on postoperative analgesia with BLIS vs fentanyl in amputation, what effect did BLIS have on postoperative sedation scores compared to fentanyl?

A. BLIS resulted in higher sedation
B. BLIS resulted in more vomiting but less sedation
C. No difference in sedation observed
D. Fentanyl caused greater sedation
E. Fentanyl caused less sedation

Answer: Fentanyl caused greater sedation

Explanation: 10/20 fentanyl dogs showed sedation vs only 2/20 in BLIS group.
In Paul 2024 et al., on postoperative analgesia with BLIS vs fentanyl in amputation, what was the median time to eating postoperatively in the BLIS group?

A. 3 hours
B. 6 hours
C. 9 hours
D. 12 hours
E. 18 hours

Answer: 6 hours

Explanation: Dogs in the BLIS group began eating earlier (median 6 h) compared to the control group.
In Paul 2024 et al., on postoperative analgesia with BLIS vs fentanyl in amputation, at which time point did BLIS show significantly lower pain scores?

A. 6 hours
B. 12 hours
C. 18 hours
D. 24 hours
E. 48 hours

Answer: 6 hours

Explanation: BLIS pain scores were significantly lower at 6 h; equivalence was not shown at this time point.
In Paul 2024 et al., on postoperative analgesia with BLIS vs fentanyl in amputation, how did postoperative vomiting compare between BLIS and fentanyl-treated dogs?

A. Similar frequency in both groups
B. Observed only in BLIS group
C. Observed only in fentanyl group
D. More frequent in BLIS group
E. BLIS caused severe vomiting

Answer: Observed only in fentanyl group

Explanation: Only fentanyl group dogs vomited (4/20); none in the BLIS group vomited.
In Paul 2024 et al., on postoperative analgesia with BLIS vs fentanyl in amputation, how many BLIS group dogs required rescue analgesia?

A. 0
B. 2
C. 5
D. 8
E. 10

Answer: 5

Explanation: Rescue analgesia was required in 5 dogs in the BLIS group and 4 in the control group.

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