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Carvajal et al: Serum acute-phase protein concentrations following uncomplicated total hip arthroplasty in dogs
Veterinary Surgery 1, 2023

🔍 Key Findings

  • C-reactive protein (CRP) and serum amyloid A (SAA) levels remained low at 3 and 6 months after uncomplicated THA in dogs.
  • No significant differences were observed in CRP or SAA between preoperative, 3-month, and 6-month time points.
  • Mean CRP values were 3.8 mg/L pre-op, 0.8 mg/L at 3 months, and 1.4 mg/L at 6 months.
  • Mean SAA values were 13.9 mg/L pre-op, 14.1 mg/L at 3 months, and 18.4 mg/L at 6 months.
  • All dogs recovered normally with no complications or persistent signs of inflammation at follow-up.
  • Study establishes baseline CRP and SAA levels for dogs post-THA, useful for comparison in suspected PJI.
  • These markers may help differentiate periprosthetic joint infection (PJI) if values deviate from baseline post-THA.
  • NSAID therapy was discontinued by 6 months in all dogs, possibly reflecting decreased inflammation.

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← Articles

Carvajal et al: Serum acute-phase protein concentrations following uncomplicated total hip arthroplasty in dogs
Veterinary Surgery 1, 2023

🔍 Key Findings

  • C-reactive protein (CRP) and serum amyloid A (SAA) levels remained low at 3 and 6 months after uncomplicated THA in dogs.
  • No significant differences were observed in CRP or SAA between preoperative, 3-month, and 6-month time points.
  • Mean CRP values were 3.8 mg/L pre-op, 0.8 mg/L at 3 months, and 1.4 mg/L at 6 months.
  • Mean SAA values were 13.9 mg/L pre-op, 14.1 mg/L at 3 months, and 18.4 mg/L at 6 months.
  • All dogs recovered normally with no complications or persistent signs of inflammation at follow-up.
  • Study establishes baseline CRP and SAA levels for dogs post-THA, useful for comparison in suspected PJI.
  • These markers may help differentiate periprosthetic joint infection (PJI) if values deviate from baseline post-THA.
  • NSAID therapy was discontinued by 6 months in all dogs, possibly reflecting decreased inflammation.

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Multiple Choice Questions on this study

In Carvajal 2023 et al., on serum biomarkers post-THA, which statement best describes SAA trends after surgery?

A. Levels peaked at 3 months and normalized by 6 months
B. Levels were significantly higher than preoperative levels
C. Levels showed no significant change at 3 or 6 months
D. Levels dropped sharply at 6 months
E. Levels became undetectable

Answer: Levels showed no significant change at 3 or 6 months

Explanation: SAA remained consistent across all time points, indicating a stable postoperative course.
In Carvajal 2023 et al., on serum biomarkers post-THA, what was the significance of including only dogs with uncomplicated THA?

A. It allowed analysis of trauma-induced CRP peaks
B. It helped establish reference values in a normal recovery
C. It assessed surgical technique failure
D. It evaluated efficacy of NSAIDs
E. It examined early infection markers

Answer: It helped establish reference values in a normal recovery

Explanation: The absence of complications allowed the study to generate clean baseline data.
In Carvajal 2023 et al., on serum biomarkers post-THA, what treatment had all dogs discontinued by 6 months?

A. Antibiotics
B. NSAIDs
C. CRP testing
D. Physiotherapy
E. Cage rest

Answer: NSAIDs

Explanation: All dogs had stopped NSAID treatment by the 6-month mark, potentially reflecting reduced inflammation.
In Carvajal 2023 et al., on serum biomarkers post-THA, what was the observed trend in CRP levels from preoperative to 6-month follow-up?

A. They significantly increased
B. They returned to baseline from a high peak
C. They remained elevated
D. They significantly decreased
E. They remained low and stable

Answer: They remained low and stable

Explanation: The study found no significant change across time points, with CRP levels staying within normal limits.
In Carvajal 2023 et al., on serum biomarkers post-THA, what is the clinical implication of stable CRP and SAA levels postoperatively?

A. It confirms joint osseointegration
B. It rules out surgical trauma
C. It may help screen for PJIs
D. It indicates analgesic efficacy
E. It proves antibiotic effectiveness

Answer: It may help screen for PJIs

Explanation: Deviations from baseline in future cases could suggest infection.

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